The U.S. Meals and Drug Management has given an organization the OK to provide customers a house DNA test for genetic mutations related to breast and/or ovarian most cancers. Is the use of the test a great way to decide your menace?
"While the self-test is easy to complete, and you can do it conveniently from your home, its usefulness is limited," cautions Holly Pederson, MD, Director of Clinical Breast Products and services.
How Had At-Home Checking Done?
The house DNA test calls for no prescription can also be ordered online and calls for filing a saliva pattern. A lab analyzes DNA from cells to your saliva to seem for 3 pathogenic variants within the BRCA gene, two in BRCA1 and one in BRCA2.
Those produce a far upper menace for breast and/or ovarian most cancers that are observed within the common inhabitants. The mutations too can reason prostate or breast most cancers in males.
"There is a minimum of 1,000 recognized BRCA mutations most definitely many extra and this test handiest accounts for the 3 maximum commonplace mutations observed within the Jewish inhabitants," Dr. Pederson explains.
The 3 BRCA1/BRCA2 mutations referred to as Ashkenazi founder mutations normally don't happen in different populations. while you're of Ashkenazi descent, your likelihood of getting a BRCA1 or BRCA2 gene mutation is an alarming 1 in 40, in comparison to one in 400 to 500 for the overall inhabitants.
"The DNA self-test is a pretty good screen for most Jewish people, but it may not go far enough," says Dr. Pederson. It monitors for the BRCA1 and BRCA2 mutations that account for 80 to 90 % of the cancer-causing mutations observed within the Jewish group. But it surely does now not assessment different high-risk genes, together with different BRCA genes and just about a dozen extra genes which were known.
"Additionally, families may share other less significant genes or environmental exposures that contribute to risk, even when a specific gene mutation is not identified," explains Dr. Pederson. "So patients whose home DNA tests are negative may still benefit from MRI screening or preventive medication."
Genetic Counseling: The Thing To Figure Out Your Menace
Dr. Pederson recommends operating with a genetic counselor irrespective of ancestry in case you have:
A robust non-public or circle of relatives historical past of breast most cancers.
Any non-public or circle of relatives historical past of ovarian most cancers, male breast most cancers or pancreatic most cancers.
The genetic counselor helps you perceive which test is easiest, watch for imaginable effects, speak about menace relief methods and interpret test effects.
Having a gene mutation doesn't imply you'll get most cancers; it handiest approach your menace of most cancers menace is upper. Choices for managing your menace come with being watched extra moderately, taking into consideration drugs to cut back your menace and even pursuing risk-reducing surgical procedures. Nonetheless, "finding out you are at high risk for breast or ovarian cancer is terrifying," says Dr. Pederson. "Having a relationship with a healthcare provider beforehand that you can turn to afterward — especially if the news is rough — is important. I think that's really missed with the at-home testing."